Vitamin B-6 metabolism in phenylketonuric patients

Kharitonchik L.A.1, Kodentsova V.M.1, Vrzhesinskaya O.A.1, Denisova S.N.1, Sprichev V.B.1

1. Institute of Nutrition at Russian Medical Academy
PubMed Id: 10802890
Year: 2000  Volume: 46  Issue: 1  Pages: 81-88
Based on the analysis of the dependence of 4-pyridoxic acid urinary excretion from pyridoxal-5'-phosphate blood plasma level and its statistic distribution it has been shown that vitamin B-6 metabolism in children suffering from phenylketonuria and therefore the criteria of the body saturation with this vitamin differ from those for healthy people. Increased pyridoxal-5'-phosphate blood plasma level has been demonstrated for PKU children. The concentration of 11 ng/ml shoud be considered as a bottom border of the adequate supply with vitamin B-6. The elevated vitamin B-2 intake approximates vitamin B-6 status indexes of sick children to those usually measured in healthy children. The necessity for the reevaluation of vitamin B-2 and B-6 optimal diet content under this disease and its biochemical validation are discussed.
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Keywords: Vitamin B-6, vitamin B-2, criteria of vitamin supply

Kharitonchik, L. A., Kodentsova, V. M., Vrzhesinskaya, O. A., Denisova, S. N., Sprichev, V. B. (2000). Vitamin B-6 metabolism in phenylketonuric patients. Voprosy Meditsinskoi Khimii, 46(1), 81-88.
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