VOPROSY MEDITSINSKOI KHIMII (ISSN 0042-8809)

Protein synthesis in heart muscle and the cardioprotective effect of m -opioid receptor ligands at immobilization stress

   
Naryznaya N.V.1, Maslov L.N.1, Lishmanov Yu.B.1

1. Laboratory of Experimental Cardiology, Tomsk Institute of Cardiology
PubMed Id: 10885032
Year: 2000  Volume: 46  Issue: 2  Pages: 127-154
Immobilization stress leads to the increase of 99mТс-pyrophosphate accumulation in the heart that points to the cardiomyocyte damage. The stress-reaction was accompanied by a decrease of protein synthesis rate in the heart muscle and immunoreactive insulin level in blood plasma and increase of blood plasma cortisol and aldosteron. Pretreatment with agonists m -opioid receptors DALDA and DAGO (0,1 mg/kg intraperitonealy (i.p.) twice during stress) completely prevented the stress-induction decrease of myocardial protein synthesis rate, heart damage and hormonal imbalance. Cycloheximide administration (0,3 mg/kg i.p.) increased rats myocardial membrane injury during immobilization and reduced cardioprotective effect of DALDA
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Keywords: stress, myocardial protein synthesis, enkephalins, hormones
Citation:

Naryznaya, N. V., Maslov, L. N., Lishmanov, Yu. B. (2000). Protein synthesis in heart muscle and the cardioprotective effect of m -opioid receptor ligands at immobilization stress. Voprosy Meditsinskoi Khimii, 46(2), 127-154.
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