VOPROSY MEDITSINSKOI KHIMII (ISSN 0042-8809)

The comparison study of vanadium-compounds with insulin-mimetic properties

   
Golubev M.A.1, Gorodetsky V.K.1, Aniskina A.P.1, Tochilkin A.I.1, Belyaeva N.F.1

1. Institute of Biomedical Chemistry RAMS, Moscow, Russia
PubMed Id: 10885036
Year: 2000  Volume: 46  Issue: 2  Pages: 155-161
The serum glucose concentration, HbAc1, fructoseamine, the activity of AST, ALT, amylase, glycogen content and glucokinase activity in rat hepatocytes were examined in streptozotocin-diabetic rats during long-term orthovanadate and vanadyl sulphate treatment. The improvement of this parameters were demonstrated after oral orthovanadate and vanadyl sulphate administration. However, insulin-mimetic properties of vanadyl sulphate were more marked in comparison with orthovanadate. LD-50 and cytotoxicity analysis in isolated hepatocytes showed that vanadyl sulphate was less toxic than orthovanadate.
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Golubev M.A., Gorodetsky V.K., Aniskina A.P., Tochilkin A.I., Belyaeva N.F. (2000) Voprosy meditsinskoi khimii, 46(2), 155-161.
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