1. Russian Medical Academy for Postgraduate Education, Dept. of Biochem 2. Research Institute for Phthisiopulmonology, Moscow Medical I.Sechenov’s Academy
53 patients with lung tuberculosis were divided in 3 groups in accordance with severety of disease. Leukocyte elastase, cationic proteins in neutrophils, activities of a 1-proteinase and a 2-macroglobulin were determined in patients’ plasma. Thromboelastographic, coagulating, fibrinolytic indices, and antithrombin III activity were also determined in 28 patients of all 3 groups. Results demonstrated the high level of leukocyte elastase (6-fold more than normal) in plasma of patients with acute tuberculosis process. This group of patients demonstrated activation of intravascular coagulation proceeded on the background of significant decrease (up to 60%) of AT III activity. Conclusion: Acuity and severety of tuberculosis process in lung may be characterized by high activity of leukocyte elastase. Degranulating activity of neutrophils and releasing of elastase are the reason of AT III deficiency and increasing of intravascular coagulating activity in tuberculosis patients
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Keywords: leukocyte elastase, tuberculosis, activation of neutrophils, inflammation, AT III deficiency, thrombohaemorrage complications
Citation:
Dotsenko V.L., Spirina A.Ya., Makinsky A.I., Neshkova E.A., Yorshikova Yu.E., Yarovaya G.A. (2000) Leukocyte elastase in plasma of patients with pulmonary tuberculosis and its part in blood coagulation disturbances. Voprosy Meditsinskoi Khimii, 46(2), 176-183.
Dotsenko V.L. et al. Leukocyte elastase in plasma of patients with pulmonary tuberculosis and its part in blood coagulation disturbances // Voprosy Meditsinskoi Khimii. - 2000. - V. 46. -N 2. - P. 176-183.
Dotsenko V.L. et al., "Leukocyte elastase in plasma of patients with pulmonary tuberculosis and its part in blood coagulation disturbances." Voprosy Meditsinskoi Khimii 46.2 (2000): 176-183.
Dotsenko, V. L., Spirina, A. Ya., Makinsky, A. I., Neshkova, E. A., Yorshikova, Yu. E., Yarovaya, G. A. (2000). Leukocyte elastase in plasma of patients with pulmonary tuberculosis and its part in blood coagulation disturbances. Voprosy Meditsinskoi Khimii, 46(2), 176-183.
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