The work represents an introduction article of editors of special issue of the magazine devoted to gene therapy and therapeutics. The main results of clinical gene therapy in the past decade are critically considered in connection with a changes of paradigms of the field. They are: 1) change of the main target of genetic therapy – correction of defects in chromosomes - onto expression and/or output of target genes for gene therapy; 2) transfer from gene transplantation to cell transplantation; 3) tendency for the use of safe/non-viral vectors insted of viral ones.; and 4) conflict of interests in gene therapy. Outlooks in the field are discussed
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Keywords: Gene therapy, paradigms of gene therapy, gene-cell therapy, therapeutics genes, viral and non-viral vectors, clinical protocols, ethical problems
Citation:
Zhdanov R.I., Semenova N.V., Archakov A.I. (2000) Realities and hopes of gene therapy. Voprosy Meditsinskoi Khimii, 46(3), 197-206.
Zhdanov R.I. et al. Realities and hopes of gene therapy // Voprosy Meditsinskoi Khimii. - 2000. - V. 46. -N 3. - P. 197-206.
Zhdanov R.I. et al., "Realities and hopes of gene therapy." Voprosy Meditsinskoi Khimii 46.3 (2000): 197-206.
Zhdanov, R. I., Semenova, N. V., Archakov, A. I. (2000). Realities and hopes of gene therapy. Voprosy Meditsinskoi Khimii, 46(3), 197-206.
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