VOPROSY MEDITSINSKOI KHIMII (ISSN 0042-8809)

Listeria monocytogenes: nasty pathogen but useful tool for vaccine development

   
Tkachuk M.V.1, Yarovinsky F.O.2, Tonevitsky A.G.3

1. Stanford University, B259 Campus Dr., CA 94305, USA
2. Belozerskiy Institute of Lomonosov Moscow State University, 119899 Moscow
3. Institute of Transplantation and Artificial Organs, 123182 Moscow
PubMed Id: 11033885
Year: 2000  Volume: 46  Issue: 3  Pages: 256-263
Listeria monocytogenes (LM) has become a major pathogen of human foodborne illnesses eliciting meningitis, peritonitis, and abortions with a mortality rate of about 30%. During the course of the disease, LM infects a variety of tissues and cell types due to its capacity to induce its own phagocytosis even into non-phagocytic cells. For over 35 years LM continues to serve as a model to define general paradigms of immunology In this review we focus on the clinical characteristics of listeriosis, on the risk factors involved in the pathogenesis, and discuss the currently accepted approaches to prophylaxis and treatment. We report on novel strategies in vaccine development based on the LM-dependent delivering machinery for immune recognition and induction of immunological memory against desired antigens.
Download PDF:
Reference:

Tkachuk M.V., Yarovinsky F.O., Tonevitsky A.G. (2000) Voprosy meditsinskoi khimii, 46(3), 256-263.
References  
 2002 (vol 48)
 2001 (vol 47)
 2000 (vol 46)
 1999 (vol 45)
 1998 (vol 44)
 1997 (vol 43)
 1996 (vol 42)
 1995 (vol 41)
 1994 (vol 40)
 1993 (vol 39)
 1992 (vol 38)
 1991 (vol 37)
 1990 (vol 36)
 1989 (vol 35)
 1988 (vol 34)
 1987 (vol 33)
 1986 (vol 32)
 1985 (vol 31)
        

© Institute of Biomedical Chemistry, Moscow, Russia