Listeria monocytogenes: nasty pathogen but useful tool for vaccine development

Tkachuk M.V.1, Yarovinsky F.O.2, Tonevitsky A.G.3

1. Stanford University, B259 Campus Dr., CA 94305, USA
2. Belozerskiy Institute of Lomonosov Moscow State University, 119899 Moscow
3. Institute of Transplantation and Artificial Organs, 123182 Moscow
PubMed Id: 11033885
Year: 2000  Volume: 46  Issue: 3  Pages: 256-263
Listeria monocytogenes (LM) has become a major pathogen of human foodborne illnesses eliciting meningitis, peritonitis, and abortions with a mortality rate of about 30%. During the course of the disease, LM infects a variety of tissues and cell types due to its capacity to induce its own phagocytosis even into non-phagocytic cells. For over 35 years LM continues to serve as a model to define general paradigms of immunology In this review we focus on the clinical characteristics of listeriosis, on the risk factors involved in the pathogenesis, and discuss the currently accepted approaches to prophylaxis and treatment. We report on novel strategies in vaccine development based on the LM-dependent delivering machinery for immune recognition and induction of immunological memory against desired antigens.
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Keywords: Listena monocytogenes, listenosis, phagocytosis, vaccine

Tkachuk, M. V., Yarovinsky, F. O., Tonevitsky, A. G. (2000). Listeria monocytogenes: nasty pathogen but useful tool for vaccine development. Voprosy Meditsinskoi Khimii, 46(3), 256-263.
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