The experiments have shown that even resection of relatively small (15-20%) portion of the intact liver resulted in significant changes of glutamine metabolism in hepatocytes, which were not eliminated for 21 days of postoperative period. The changes of the activity of key enzymes of glutamine metabolism, glutamine synthetase and glutaminase (phosphate-dependent), are responsible for these alterations. The changes of activity of these enzymes closely depend on the location of hepatocytes to focus of mechanical damage.
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