The synthesized peptides represent the functionally important site for binding to insulin receptor. Amino acids of peptide I correlate with B-chain of insulin at the position B19-B26 and A-chain at the position A20-A21. Amino acids of peptide II correlate with B-chain of insulin at position B23-B26 and A-chain at the position A20-A21. It was shown, that the these peptides increased liposomal binding followed by receptor-mediated endocytosis by cells PC12.
Maslov D.L., Prozorovskiy V.N. (2000) The study of the interaction liposomes coated by synthetic fragments of insulin with PC12 cells. Voprosy Meditsinskoi Khimii, 46(4), 377-383.
Maslov D.L. et al. The study of the interaction liposomes coated by synthetic fragments of insulin with PC12 cells // Voprosy Meditsinskoi Khimii. - 2000. - V. 46. -N 4. - P. 377-383.
Maslov D.L. et al., "The study of the interaction liposomes coated by synthetic fragments of insulin with PC12 cells." Voprosy Meditsinskoi Khimii 46.4 (2000): 377-383.
Maslov, D. L., Prozorovskiy, V. N. (2000). The study of the interaction liposomes coated by synthetic fragments of insulin with PC12 cells. Voprosy Meditsinskoi Khimii, 46(4), 377-383.
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