VOPROSY MEDITSINSKOI KHIMII (ISSN 0042-8809)

The study of the interaction liposomes coated by synthetic fragments of insulin with PC12 cells

   
Maslov D.L.1, Prozorovskiy V.N.1

1. Institute of Biomedical Chemistry RAMS
PubMed Id: 11075420
Year: 2000  Volume: 46  Issue: 4  Pages: 377-383
The synthesized peptides represent the functionally important site for binding to insulin receptor. Amino acids of peptide I correlate with B-chain of insulin at the position B19-B26 and A-chain at the position A20-A21. Amino acids of peptide II correlate with B-chain of insulin at position B23-B26 and A-chain at the position A20-A21. It was shown, that the these peptides increased liposomal binding followed by receptor-mediated endocytosis by cells PC12.
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Maslov D.L., Prozorovskiy V.N. (2000) Voprosy meditsinskoi khimii, 46(4), 377-383.
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