Research of catecholamine metabolism peculiarities of the children with attention deficithyperactivity disorder

Kasatikova H.V.1, Larionov N.P.1, Popkova H.V.2, Briazgunov I.P.3

1. Vladimir State Pedagogical University, Department of Chemistry
2. The Institute of General Pathology and Pathophysiology, laboratory and genetic mechanisms of adaptation
3. Scientific Center of Children's Health RAMS, Department of functional pathology
PubMed Id: 11204626
Year: 2000  Volume: 46  Issue: 5  Pages: 455-461
The aim of research was to study catecholamine excretion peculiarities of the children with attention deficit hyperactivity disorder (ADHD). 25 children at the age of 7-9 years took part in this research. High-pressure liquid chromatography (HPLC) was used for measuring the content of catecholamine. The content of catecholamine was defined in the morning samples of urine. The examination showed, that ADHD children had the basal level of epinephrine and norepinephrine more than the normal control in 3,9 and 5,4 times. After cognitive tests the c опtent of norepinephrine reduced in the ADHD group in 2,1 times in the comparison with normal control. On the contrary content of epinephrine increased in 2,8 times. Conclusion: Simpatico-adrenal system hyperactivity (especially it’s adrenals component) characterized ADHD children
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Kasatikova H.V., Larionov N.P., Popkova H.V., Briazgunov I.P. (2000) Voprosy meditsinskoi khimii, 46(5), 455-461.
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