VOPROSY MEDITSINSKOI KHIMII (ISSN 0042-8809)

Bacterial L-asparaginase and glutamin(asparagin)ase: some properties, structure and anti-tumor activity

   
Sokolov N.N.1, Zanin V.A.2, Alexandrova S.S.1

1. Orechovich Institute of Biomedical Chemistry RAMS
2. Peoples’ Friendship University, Russia
PubMed Id: 11234278
Year: 2000  Volume: 46  Issue: 6  Pages: 531-548
Еxperimental material on structurally and functional organization, regulation of biosynthesis and activity, mechanism of action, genetic determinants, heterologous expression of bacterial L-asparaginases is accumulated. The modern approaches to isolation and purification of these enzymes, some questions of practical using in oncology in the schedules combined chemotherapy of leukemia the native and modified forms of L-asparaginases are discussed. The some results before carried out in the IBMC RAMS and number institutes of the Russia on study bacterial L-asparaginases and glutamine(asparagine)ases are summarized.
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Sokolov N.N., Zanin V.A., Alexandrova S.S. (2000) Voprosy meditsinskoi khimii, 46(6), 531-548.
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