VOPROSY MEDITSINSKOI KHIMII (ISSN 0042-8809)

Impairments of antioxidative homeostasis in patients with arterial hypertension: implications for pathogenesis

   
Paranich A.V.1, Lad S. N.2, Frolova N. A.1, Snegurskaya I.A.3, Koval S. N.3

1. Karazin National University, Kharkov, Ukraine
2. Kharkov State medical Institute, Ukraine
3. Institute of Therapy, National Academy of Medical sciences, Kharkov, Ukraine
PubMed Id: 11234283
Year: 2000  Volume: 46  Issue: 6  Pages: 591-596
Antioxidative homeostasis was investigated in blood plasma and lymphocytes of patients with hypertonic disease (stage II). The intensification of lipid peroxidation was accompanied by accumulation of polyenic fatty acid derivatives and toxic dialdehydes and also by mobilization of lipid soluble vitamins. Vitamin E is probably involved into direct binding of toxic LPO products. Such changes provide high antioxidant activity and normal functioning of lymphocytes.
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Paranich A.V., Lad S. N., Frolova N. A., Snegurskaya I.A., Koval S. N. (2000) Voprosy meditsinskoi khimii, 46(6), 591-596.
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