VOPROSY MEDITSINSKOI KHIMII (ISSN 0042-8809)

Impairments of carbohydrate metabolism at the combination of lung tuberculosis and diabetus mellitus in patients with the different phenotypes of haptoglobin

   
Parpieva N.N.1, Kazakov S.S.2

1. Research Institute of Phthisiology and Pulmonology, Tashkent, Republic of Uzbekistan
2. Research Institute of Phthisiology and Pulmonology, Tashkent, Republic of Uzbekistan
PubMed Id: 11234285
Year: 2000  Volume: 46  Issue: 6  Pages: 610-614
Sugar level in blood, the activity of lactate dehydrogenase (LDH), glucose – 6 – phosphate dehydrogenase (G-6-PDH), 2,3 – BPG content, HbA1C and the phenotype of haptoglobin were studied in 180 patients with lung tuberculosis and diabetes mellitus. The increased (2-4.2-fold) blood sugar level was found in 77,2% patients. It was accompanied by decreased activity of LDH (by 1.3-1.7 times), G-6-PDH (by 15 – 45% in 87% patients). In patients with various haptoglobin phenotypes the content of HbA1C and 2.3-BPG was increased by 1.5-1.7and 2-3 times, respectively. Clear differences in the studied parameters were found in patients with various phenotypes of haptoglobin (Hp). The most serious impairments of the studied parameters of carbohydrate metabolism were found in untreated patients with homozygote Hp phenotypes 2 – 2 and 1 – 1
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Reference:

Parpieva N.N., Kazakov S.S. (2000) Voprosy meditsinskoi khimii, 46(6), 610-614.
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