A new approach to overcome the degradation of insulin by proteolytic enzymes and its targeting to the blood through the digestive apparatus was developed. The approach is based on the immobilization of insulin into the polymeric hydrogel which is modified by ovomucoid--glycoprotein, inhibitor of proteolytic enzymes. Oral administration of this system to rabbits and rats, (in contrast to the hydrogels modified by proteolytic enzymes inhibitors without polysaccharide part), statistically significantly lowered blood glucose level.
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Valuev I.L., Sytov G.A., Valuev L.I., Valueva T.A., Ul'yanova M.V., Plate N.A. (2001) Inhibitors of proteolytic enzymes in the therapy of diabetes. Voprosy Meditsinskoi Khimii, 47(1), 132-154.
Valuev I.L. et al. Inhibitors of proteolytic enzymes in the therapy of diabetes // Voprosy Meditsinskoi Khimii. - 2001. - V. 47. -N 1. - P. 132-154.
Valuev I.L. et al., "Inhibitors of proteolytic enzymes in the therapy of diabetes." Voprosy Meditsinskoi Khimii 47.1 (2001): 132-154.
Valuev, I. L., Sytov, G. A., Valuev, L. I., Valueva, T. A., Ul'yanova, M. V., Plate, N. A. (2001). Inhibitors of proteolytic enzymes in the therapy of diabetes. Voprosy Meditsinskoi Khimii, 47(1), 132-154.
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