Apolipoprotein E mediates lipoprotein binding to the low density lipoprotein (LDL) receptor and to the LDL receptor-related protein. Apolipoprotein E139-158 peptide increases micellar binding and endocytosis by hepatocytes. The lipophilicity of the peptide was increased by modification of its N- terminus by acylation with palmitic acid ether. The peptide mediates acute clearance of the lipoproteins and decreases the cholesterol level in rat blood. Total cholesterol level, high density lipoprotein cholesterol and apolipoprotein B were measured in the serum after intravenous administration of the acylated peptide.
Download PDF:
Citation:
Lokhov P.G., Ipatova O.M., Prozorovskii V.N. (2001) An apolipoprotein E peptide analog mediates acute clearance of the lipoproteins and decreases the serum cholesterol level. Voprosy Meditsinskoi Khimii, 47(2), 227-235.
Lokhov P.G. et al. An apolipoprotein E peptide analog mediates acute clearance of the lipoproteins and decreases the serum cholesterol level // Voprosy Meditsinskoi Khimii. - 2001. - V. 47. -N 2. - P. 227-235.
Lokhov P.G. et al., "An apolipoprotein E peptide analog mediates acute clearance of the lipoproteins and decreases the serum cholesterol level." Voprosy Meditsinskoi Khimii 47.2 (2001): 227-235.
Lokhov, P. G., Ipatova, O. M., Prozorovskii, V. N. (2001). An apolipoprotein E peptide analog mediates acute clearance of the lipoproteins and decreases the serum cholesterol level. Voprosy Meditsinskoi Khimii, 47(2), 227-235.
References
Myant N.B. (1981). The Biology of Cholesterol and Related Steroids. William Heinemann Medical Books, London. Scholar google search
Bard J.M., Agncmi G., Cardelin L., et al. (1989). Intern. Atheroscler. Congress. Viena, Abstr.20. Scholar google search
