Using primary culture of hepatocytes it was shown that glycochenodeoxycholic acid (GCDCA) in a dose dependent manner induces apoptosis or necrosis of the hepatocytes and inhibits DNA biosynthesis. Ursodeoxycholic acid (UDCA) and tauroursodexycholic acid (TUDCA) do not cause apoptosis or necrosis of the hepatocytes in a range of doses 25-400 micrograms/ml. But in the presence of GCDCA both preparations have an antiapoptosogenic effect and TUDCA has also an antinecrosogenic effect.
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Danchenko E.O. (2001) Effects of bile acids on the DNA biosynthesis, apoptosis and necrosis of hepatocytes in vitro. Voprosy Meditsinskoi Khimii, 47(2), 236-242.
et al. Effects of bile acids on the DNA biosynthesis, apoptosis and necrosis of hepatocytes in vitro // Voprosy Meditsinskoi Khimii. - 2001. - V. 47. -N 2. - P. 236-242.
et al., "Effects of bile acids on the DNA biosynthesis, apoptosis and necrosis of hepatocytes in vitro." Voprosy Meditsinskoi Khimii 47.2 (2001): 236-242.
Danchenko, E. O. (2001). Effects of bile acids on the DNA biosynthesis, apoptosis and necrosis of hepatocytes in vitro. Voprosy Meditsinskoi Khimii, 47(2), 236-242.
References
Greim R., Trulzsch D., Czygan P. et al. (1972). Gastroenterology. 63, 837- 845. Scholar google search
Patel Т., Bronk S.F., Gores G.J. (1994) J. Clin. Invest. 94, 2183- 2192. Scholar google search
Gerschenson L.E., Rotello R.J. (1992). FASEB J. 6, 2450- 2455. Scholar google search
Wyllie A.H., Ken J.F.R. Currie A.R. (1980). Int. Rev. Cytol. 68,251- 306. Scholar google search
Leuschner U., Fischer H., Kurtz W. et al.(1989). Gastroenterology. 97, 1268- 1274. Scholar google search
Beuers U., Spengler U., Kruis W. et al. (1992). Hepatology. 16, 707- 714. Scholar google search
Crosignani A., Budillon G., Cimino L. et al. (1998). Hepatogastroenterology. 45, 1624- 1629. Scholar google search
Rodrigues С.М., Kren B.T., Steer C.J. et al. (1995). Gastroenterology. 105, 564- 572. Scholar google search
Zimmerman T., Franke H., Peuker M., Dargel R. (1992). J.Hepatol. 15,10- 16. Scholar google search
Greim H., Czygan P., Schaffner F. (1973). Biochem. Med., 8, 280- 286. Scholar google search
Benz Ch., Angermtiller S., Tox U., et al. (1998). J. Hepatology. 28, 99- 106. Scholar google search
Bomzon A., Ljubuncic P. (1995). Biochem. Pharmacol., 49, 581- 589. Scholar google search
Anwer M.S., Engelking L.R., Nolan K. et al. (1991). Hepatology. 8, 887- 891. Scholar google search
Spivey J., Bronk S., Gores G. (1993). J.Clin Invest., 92, 17- 24. Scholar google search
Kwo P., Patel Т., Bronk S., Gores G. (1995). Am. J. Physiol., 268, G.613- 662. Scholar google search
Webster C.R.L., Anwer M.S. (1998). Hepatology., 27, 1324- 1331. Scholar google search
Faubion W.A., Guicciardi M.E., Migoshi H. et al. (1999). J. Clin. Invest., 103, 137- 145. Scholar google search
Rodrigues C.M.P. (1998). Simp.update on bilirubin and bile acid metabolism related inborn errors and new therapies 15- 18. Scholar google search
Invernizzi P., Selchell K.D., Crosignani A. (1999). Hepatology. 29. 320- 327. Scholar google search
