VOPROSY MEDITSINSKOI KHIMII (ISSN 0042-8809)

Effects of bile acids on the DNA biosynthesis, apoptosis and necrosis of hepatocytes in vitro

   
Danchenko E.O.1

1. Vitebsk Medical University
PubMed Id: 11450444
Year: 2001  Volume: 47  Issue: 2  Pages: 236-242
Using primary culture of hepatocytes it was shown that glycochenodeoxycholic acid (GCDCA) in a dose dependent manner induces apoptosis or necrosis of the hepatocytes and inhibits DNA biosynthesis. Ursodeoxycholic acid (UDCA) and tauroursodexycholic acid (TUDCA) do not cause apoptosis or necrosis of the hepatocytes in a range of doses 25-400 micrograms/ml. But in the presence of GCDCA both preparations have an antiapoptosogenic effect and TUDCA has also an antinecrosogenic effect.
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Reference:

Danchenko E.O. (2001) Voprosy meditsinskoi khimii, 47(2), 236-242.
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