Thioacetamide administration to rats (20 mg/100 g) caused the development of toxic hepatitis which was accompanied by the increase of hepatic ALA-synthase and D-ALA that led to accumulating free porphyrines in the liver. At the same time an increase in activity of heme oxigenase was also found. A decrease in heme synthesis correlated with a decrease in content of cytochrome P450 and b5 in microsomal hepatic fraction of experimental animals.
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Karimov Kh.Ya., Inoyatova F.H., Dolimova M.A. (2001) Effect of acute thioacetamide- induced hepatitis on theactivity of heme-metabolising enzymes and content of microsomal hemoproteins. Voprosy Meditsinskoi Khimii, 47(2), 243-247.
Karimov Kh.Ya. et al. Effect of acute thioacetamide- induced hepatitis on theactivity of heme-metabolising enzymes and content of microsomal hemoproteins // Voprosy Meditsinskoi Khimii. - 2001. - V. 47. -N 2. - P. 243-247.
Karimov Kh.Ya. et al., "Effect of acute thioacetamide- induced hepatitis on theactivity of heme-metabolising enzymes and content of microsomal hemoproteins." Voprosy Meditsinskoi Khimii 47.2 (2001): 243-247.
Karimov, Kh. Ya., Inoyatova, F. H., Dolimova, M. A. (2001). Effect of acute thioacetamide- induced hepatitis on theactivity of heme-metabolising enzymes and content of microsomal hemoproteins. Voprosy Meditsinskoi Khimii, 47(2), 243-247.
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