Antioxidant properties of analogues of 3-oxypyridine: mexidol, emoxipin, proxipin

Klebanov G.I.1, Lyubitsky O.B.1, Vasiljeva O.V.1, Klimov Yu.A.2, Penzulaeva O.B.2, Teplyashin A.S.2, Tolstyh M.P.3, Promorenko V.K.4, Vladimirov Yu.A.1

1. Department of Biophysic, Russian State Medical University
2. State Research Center for Laser Medicine Health Ministry
3. Moscow Medico-Dental University
4. TOO "Science Center"
PubMed Id: 11558311
Year: 2001  Volume: 47  Issue: 3  Pages: 288-300
Using three chemiluminescent model systems of oxidation (suspension of phospholipid liposomes, a geous solution of haemoglobin - hydrogen peroxide - luminol and a geous solution 2,2'-azo-bis-(2-methylpropionamidine)dihydrochloride - luminol) the antioxidant activity and mechanism of antioxidant action of three 3-oxypyridine analogues: (mexidol, emoxipin and proxipin) were studied. These compounds were shown: a) to interact with catalitically active two valency iron ions (Fe2+), that causes elimination of ions from the model system; b) to scavenge reactive oxygen species and/or luminol radicals produced in the model systems. Their activity reduced in the following order: mexidol > emoxipin > proxipin. The antioxidant activity of 3-oxypyridines may underline known clinical effects of these compounds
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Klebanov, G. I., Lyubitsky, O. B., Vasiljeva, O. V., Klimov, Yu. A., Penzulaeva, O. B., Teplyashin, A. S., Tolstyh, M. P., Promorenko, V. K., Vladimirov, Yu. A. (2001). Antioxidant properties of analogues of 3-oxypyridine: mexidol, emoxipin, proxipin. Voprosy meditsinskoi khimii, 47(3), 288-300.
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