1. Department of Biophysic, Russian State Medical University 2. State Research Center for Laser Medicine Health Ministry 3. Moscow Medico-Dental University 4. TOO "Science Center"
Using three chemiluminescent model systems of oxidation (suspension of phospholipid liposomes, a geous solution of haemoglobin - hydrogen peroxide - luminol and a geous solution 2,2'-azo-bis-(2-methylpropionamidine)dihydrochloride - luminol) the antioxidant activity and mechanism of antioxidant action of three 3-oxypyridine analogues: (mexidol, emoxipin and proxipin) were studied. These compounds were shown: a) to interact with catalitically active two valency iron ions (Fe2+), that causes elimination of ions from the model system; b) to scavenge reactive oxygen species and/or luminol radicals produced in the model systems. Their activity reduced in the following order: mexidol > emoxipin > proxipin. The antioxidant activity of 3-oxypyridines may underline known clinical effects of these compounds
Klebanov G.I. et al. Antioxidant properties of analogues of 3-oxypyridine: mexidol, emoxipin, proxipin // Voprosy Meditsinskoi Khimii. - 2001. - V. 47. -N 3. - P. 288-300.
Klebanov G.I. et al., "Antioxidant properties of analogues of 3-oxypyridine: mexidol, emoxipin, proxipin." Voprosy Meditsinskoi Khimii 47.3 (2001): 288-300.
Klebanov, G. I., Lyubitsky, O. B., Vasiljeva, O. V., Klimov, Yu. A., Penzulaeva, O. B., Teplyashin, A. S., Tolstyh, M. P., Promorenko, V. K., Vladimirov, Yu. A. (2001). Antioxidant properties of analogues of 3-oxypyridine: mexidol, emoxipin, proxipin. Voprosy Meditsinskoi Khimii, 47(3), 288-300.
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