VOPROSY MEDITSINSKOI KHIMII (ISSN 0042-8809)

The influence of y-L-glutamylhistamine analogues on the severity of experimental anaphylactic reaction, hormonal status and liver cytochrome P450

   
Nebolsin V.E.1, Zheltukhina G.A.1, Krzechkovskaya V.V.1, Kovaleva V.L.1, Evstigneeva R.P.1

1. Lomonosov Moscow State Academy of Fine chemical Tekhnology
PubMed Id: 11558312
Year: 2001  Volume: 47  Issue: 3  Pages: 301-307
The influence of gamma-L-glutamylhistamine analogues on the hexenal-induced sleeping, glucocorticoid hormone content in blood plasma and severity of experimental anaphylactic reaction was studied. It was observed that gamma-L-glutamylhistamine analogues caused decrease in the sleeping time and severity of experimental anaphylactic reaction, the elevation of glucocorticoids content in blood plasma. The present results indicate that substances have the wide spectrum of biological activity which depends on the length of the N-acyl radical.
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Nebolsin V.E., Zheltukhina G.A., Krzechkovskaya V.V., Kovaleva V.L., Evstigneeva R.P. (2001) Voprosy meditsinskoi khimii, 47(3), 301-307.
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