VOPROSY MEDITSINSKOI KHIMII (ISSN 0042-8809)

Insulin degradation in hepatocytes and erythrocytes from normal and experimental diabetic rats

   
Nikolaev S.L.1, Strelkova M.A.1, Komov V.P.1

1. Department of Biochemistry, Saint-Petersburg State Chemical Pharmaceutical Academy
PubMed Id: 11558315
Year: 2001  Volume: 47  Issue: 3  Pages: 329-337
Insulin metabolism in erythrocytes and hepatocytes of normal and experimental diabetic rats was studied. Insulin-degrading complex of erythrocytes and hepatocytes was investigated at low insulin concentration in blood. Kinetic parameters of insulinase depend on insulin concentration in blood have shown. Thermo-acid resistant non-competitive endogenous inhibitors were purified from erythrocytes and hepatocytes. Increase of endogenous inhibitors influence insulin-degrading enzyme in diabetes. Synthesis of insulin-degrading enzyme in hepatocytes of diabetic rats was reduced. These results suggest that insulin-degrading activity in erythrocytes and hepatocytes is regulated by endogenous inhibitors, by synthesis of insulinase. This change of blood insulin concentration influences practically all the components of insulin-degrading complex.
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Nikolaev, S. L., Strelkova, M. A., Komov, V. P. (2001). Insulin degradation in hepatocytes and erythrocytes from normal and experimental diabetic rats. Voprosy meditsinskoi khimii, 47(3), 329-337.
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