VOPROSY MEDITSINSKOI KHIMII (ISSN 0042-8809)

The involvement of antioxidant enzymes in the cardioprotective effect of d-opioids during oxidative stress

   
Rebrova T.Yu.1, Maslov L.N.1, Tam S.W.2

1. Institute of Cardiology, Tomsk, Russia
2. 'NitroMed', Bedford, Massachusetts, USA
PubMed Id: 11558316
Year: 2001  Volume: 47  Issue: 3  Pages: 338-345
Intravenous administration of peptide d2-opioid receptor agonists increased cardiac sarcolemma resistance to subsequent oxidative stress in the isolated perfused rat heart in vitro. d-Opioid receptor stimulation prevented oxidative stress-induced accumulation of lipid peroxides in myocardium and inhibition of superoxide dismutase. The cardioprotective and 'antioxidant' effects of d-agonists were completely abolished by in vivo pretreatment with the b-receptor antagonist ICI 174,864. µ-Opioid receptor activation in vivo did not protect the isolated myоcardium from cardiotoxic action of activated oxygen species
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Rebrova, T. Yu., Maslov, L. N., Tam, S. W. (2001). The involvement of antioxidant enzymes in the cardioprotective effect of d-opioids during oxidative stress . Voprosy Meditsinskoi Khimii, 47(3), 338-345.
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