VOPROSY MEDITSINSKOI KHIMII (ISSN 0042-8809)

Molecular mechanisms of metabolic adaptation in liver to patological changes at toxic hepatitis

   
Zimin Yu.V.1, Syatkin S.P.2, Berezov T.T.2

1. Molecular Pathology Group, Research Institute of Traumatology and Orthopedics
2. Department of Biochemistry, Schooll of Medicine, Russian Peoples' Friendship University
PubMed Id: 11558317
Year: 2001  Volume: 47  Issue: 3  Pages: 346-352
Possible molecular mechanisms underlying changes in catalytical properties of alcohol dehydrogenase (ADH) and lactate dehydrogenase (LDH) were studied at toxic hepatitis. The development of toxic hepatitis is accompanied by significant changes in the activity of ADH and LDH assayed in subcellular fractions and kinetic characteristics of these enzymes. This can result in an increase cellular level of acetylaldehyde and lactate which promotes the development of liver cirrhosis.
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Zimin, Yu. V., Syatkin, S. P., Berezov, T. T. (2001). Molecular mechanisms of metabolic adaptation in liver to patological changes at toxic hepatitis. Voprosy meditsinskoi khimii, 47(3), 346-352.
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