VOPROSY MEDITSINSKOI KHIMII (ISSN 0042-8809)

Modulation of hepatocyte prolifaration of ischemic rat liver bytauroursodeoxycholic acid

   
Danchenko E.O.1

1. Vitebsk Medical University
PubMed Id: 11693028
Year: 2001  Volume: 47  Issue: 4  Pages: 405-410
The influence of the tauroursodeoxycholic acid (TUDCA) on hepatocyte proliferation after 180-minute ischemia of rat liver was investigated. TUDCA in a dose of 200 mg/kg did not change hepatocyte proliferation in the liver of intact rats and had no cytotoxic effect. The preliminary introduction of TUDCA accelerated regenerative processes in the liver in the postischemic period possibly due to synchronization of hepatocyte division. The membrane stabilizing effect of TUDCA manifested in reduction of the liver enzyme activity in blood serum was found.
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Danchenko, E. O. (2001). Modulation of hepatocyte prolifaration of ischemic rat liver bytauroursodeoxycholic acid. Voprosy meditsinskoi khimii, 47(4), 405-410.
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