Heparin interaction with aminogroup-containg materials
Nemets E.A.1, Kasatov D.A.2, Sevastianov V.I.3
1. Institute of Transplantology and Artifictal organs, Moskow 2. Moscow Physical-Technical Institute 3. Institute of Transplantology and Artifictal organs, Moskow, Moscow Physical-Technical Institute
The influence of the glass surface immobilized aminogroups nature and the experiments conditions on the interactions between heparin and aminogroups containing surface was studied using total internal reflections fluorescence. It was shown, that the nature of the terminating aminogroup, but not its mobility or the amount of the aminogroups in the main chain, is the major factor influencing the heparin adsorbtion from individual solution. Both the nature of terminating aminogroup and its mobility determine heparin adsorption on the aminogroups containing surfaces from the blood plasma proteins containing solution. Heparin irreversibly adsorbed from individual solution is not replaced by blood plasma proteins. The tertiary aminogroups containing surface adsorbs maximal quantity of the heparin
Nemets E.A. et al. Heparin interaction with aminogroup-containg materials // Voprosy Meditsinskoi Khimii. - 2001. - V. 47. -N 5. - P. 526-536.
Nemets E.A. et al., "Heparin interaction with aminogroup-containg materials." Voprosy Meditsinskoi Khimii 47.5 (2001): 526-536.
Nemets, E. A., Kasatov, D. A., Sevastianov, V. I. (2001). Heparin interaction with aminogroup-containg materials. Voprosy Meditsinskoi Khimii, 47(5), 526-536.
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