Lipid peroxidation in cystic fluid of craniopharyngiomas

Arefyeva I.A.1, Semenova Zh.B.1, Korshunov A.G.1, Zubairaev M.S.1, Krasnova T.S.1, Gorelyshev S.K.1, Promyslov M.Sh.1

1. Burdenko Neurosurgical Institute, Russian Academy of Medical Sciences
PubMed Id: 11925754
Year: 2001  Volume: 47  Issue: 6  Pages: 625-632
Comparing of the craniopharyngiomas cyst fluid, collected during the surgery, with blood plasma revealed significantly enhanced lipid peroxidation and lactate accumulation in tumour cysts contents. These processes were usually more prominent in endosuprasellar than in suprasellar craniopharyngiomas. The maximum of free radical formation in conjunction with the lowest level of malondialdehyde (MDA) was observed in primary tumours with relatively high proliferation rate. Controversial parameters ratio characterised the recurrent craniopharyngiomas, and in cyst fluids of the primary tumours with low proliferation rate the medium parameter's values were observed. Thus, the estimation of free radical formation level and MDA concentration in cyst fluid of craniopharyngioma seems to be prognostic for the tumour recurrence
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Arefyeva, I. A., Semenova, Zh. B., Korshunov, A. G., Zubairaev, M. S., Krasnova, T. S., Gorelyshev, S. K., Promyslov, M. Sh. (2001). Lipid peroxidation in cystic fluid of craniopharyngiomas . Voprosy Meditsinskoi Khimii, 47(6), 625-632.
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