There is increasing evidence, that oxidized indoles, isatin, 5-hydroxyoxindole, 2-oxindole, play important regulatory functions in the brain. Isatin and 5-hydroxyoxindole share some common regulatory properties in cell cultures (Cane et al., 2000, BBRC, 276, 379), however, their effects on brain mitochondrial monoamine oxidases, a potential target for their action, have not been compared yet. Isatin acted as a rather selective monoamine oxidase B inhibitor, whereas 5-hydroxyoxindole was more selective monoamine oxidase A inhibitor, but it was less potent than that of 5-hydroxyisatin, a synthetic analogue of isatin.
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Crumeyrolle M., Tournaire M.C., Cane A., Medvedev A.E. (2002) The effect of some oxidized indoles on the activity of rat brain mitochondrialmonoamine oxidases. Voprosy Meditsinskoi Khimii, 48(2), 201-203.
Crumeyrolle M. et al. The effect of some oxidized indoles on the activity of rat brain mitochondrialmonoamine oxidases // Voprosy Meditsinskoi Khimii. - 2002. - V. 48. -N 2. - P. 201-203.
Crumeyrolle M. et al., "The effect of some oxidized indoles on the activity of rat brain mitochondrialmonoamine oxidases." Voprosy Meditsinskoi Khimii 48.2 (2002): 201-203.
Crumeyrolle, M., Tournaire, M. C., Cane, A., Medvedev, A. E. (2002). The effect of some oxidized indoles on the activity of rat brain mitochondrialmonoamine oxidases. Voprosy Meditsinskoi Khimii, 48(2), 201-203.
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