The effect of administration of 3-acetylpyridine (antivitamin B3), on rat brain serotoninergic and NAD receptor systems was investigated. The injection of 3-acetylpyridine to rats caused a decrease of NAD and serotonin content in the brain and changes in [U-14C]NAD binding to synaptic membranes, serotonin uptake by nerve endings, as well as sensitivity of this process to NAD (10-5 M). Pretreatment of animals with nicotinamide restored modulating effect of NAD
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Kuchmerovskaya T.M. (2002) The effect of NAD on brain serotoninergictransmission of rats under 3-acetylpyridine injection. Voprosy Meditsinskoi Khimii, 48(3), 264-270.
et al. The effect of NAD on brain serotoninergictransmission of rats under 3-acetylpyridine injection // Voprosy Meditsinskoi Khimii. - 2002. - V. 48. -N 3. - P. 264-270.
et al., "The effect of NAD on brain serotoninergictransmission of rats under 3-acetylpyridine injection." Voprosy Meditsinskoi Khimii 48.3 (2002): 264-270.
Kuchmerovskaya, T. M. (2002). The effect of NAD on brain serotoninergictransmission of rats under 3-acetylpyridine injection. Voprosy Meditsinskoi Khimii, 48(3), 264-270.
References
Максимович Я.Б. (1981) Фармакология и токсикология, Киев, 16, 3- 8. Scholar google search
