VOPROSY MEDITSINSKOI KHIMII (ISSN 0042-8809)

Current trendsin the pharmacotherapy of type 2 diabetesmellitus

   
Kovelman I.R.1, Tochilkin A.I.1, Belayeva N.F.1, Gorodetskii V.K.1, Knyazhev V.A.2, Tkachenko C.B.3, Semenov L.L.1, Semenova N.V.1

1. Institute of Biomedical Chemistry, Russian Academy of Medical Sciences
2. Moscow Medical Sechenov’s Academy
3. Russian Medical Academy of Postgraduate Education. The department 'General Pathology and Pathophysiology'
Section: Review
PubMed Id: 12506608
Year: 2002  Volume: 48  Issue: 4  Pages: 337-352
The pharmacological approaches to the treatment of type 2 diabetes mellitus were reviewed. Special attention was paid to the new therapeutic agents that are able to decrease plasma glucose levels. The possible mechanisms of the hypoglycemic effects are discussed. Briefly, repaginide, nateglinede and alpha-glucosidase inhibitors prevent postprandial hypoclycemia while thiazaolidinediones improve the sensitivity to insulin and vanadium compounds act as an insulin action enhancer.
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Kovelman, I. R., Tochilkin, A. I., Belayeva, N. F., Gorodetskii, V. K., Knyazhev, V. A., Tkachenko, C. B., Semenov, L. L., Semenova, N. V. (2002). Current trendsin the pharmacotherapy of type 2 diabetesmellitus. Voprosy meditsinskoi khimii, 48(4), 337-352.
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