VOPROSY MEDITSINSKOI KHIMII (ISSN 0042-8809)

A drop of mink complement kills a mouse

   
Belkin Z.P.1, Kozlov L.V. 1, Andina S.S.1, Mishin A.A.1, Guzova V.A.1, D'yakov V.L.1

1. Gabrichevsky Moscow Research Institute of Epidemiology and Microbiology of Health Ministry of Russian Federation
PubMed Id: 12506613
Year: 2002  Volume: 48  Issue: 4  Pages: 373-377
The phenomenon of fast death of mice after parenteral administration of mink serum was explained by high activity of mink complement in particular by unusually high activity of its alternative pathway of activation. the presence of antibodies to mouse erythrocytes in mink serum was necessary precondition for their lysis under action of mink complement by classical and alternative pathways. However, removal of these antibodies resulting in a cancellation of hemolysis did not effect toxicity of mink serum for nice in vivo. Partial decomplementization of mink serum zymosan completely prevented а death of animals
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Belkin, Z. P., Kozlov, L. V. ,, Andina, S. S., Mishin, A. A., Guzova, V. A., D'yakov, V. L. (2002). A drop of mink complement kills a mouse. Voprosy meditsinskoi khimii, 48(4), 373-377.
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