VOPROSY MEDITSINSKOI KHIMII (ISSN 0042-8809)

The level of autoantibodies against glutamatereceptors subunits and immunologica parameters in blood of epileptic patients

   
Bazarova V.G.1, Granstrem O.K.1, Dambinova S.A.1

1. Institute of Human Brain, Russian Academy of Sciences
PubMed Id: 12506615
Year: 2002  Volume: 48  Issue: 4  Pages: 381-387
The role of glutamate receptors in the brain spiking activity was evaluated. The electroencephalographic (EEG) spiking activity was monitored and autoreactive antibodies (aAbs) to subunits of glutamate receptors were assessed in the blood serum of epileptic and ischemic stroke patients. We showed that the level of GluR autoantibodies in blood serum of patients correlates to the intensity of the brain paroxysmal activity. These data confirm our previous observations. The level of GluR1 aABs has been proposed as a specific biomarker typical for epilepsy. This approach could be recommended as an additional criterion for diagnostic of nervous diseases such as epilepsy and ischemic stroke.
Download PDF:
Citation:

Bazarova, V. G., Granstrem, O. K., Dambinova, S. A. (2002). The level of autoantibodies against glutamatereceptors subunits and immunologica parameters in blood of epileptic patients. Voprosy meditsinskoi khimii, 48(4), 381-387.
References  
 2002 (vol 48)
 2001 (vol 47)
 2000 (vol 46)
 1999 (vol 45)
 1998 (vol 44)
 1997 (vol 43)
 1996 (vol 42)
 1995 (vol 41)
 1994 (vol 40)
 1993 (vol 39)
 1992 (vol 38)
 1991 (vol 37)
 1990 (vol 36)
 1989 (vol 35)
 1988 (vol 34)
 1987 (vol 33)
 1986 (vol 32)
 1985 (vol 31)