VOPROSY MEDITSINSKOI KHIMII (ISSN 0042-8809)

DNA oxidation by free radicals and its biomarker oxidizedguanosine (8-oxodG)

   
Zinovjeva V.N.1, Ostrovsky O.V.1

1. Pharmacological Research Institute and Department of Pharmacology of Volgograd Medical Academy
Section: Review
PubMed Id: 12498082
Year: 2002  Volume: 48  Issue: 5  Pages: 419-431
Endogenous free radicals, in particular, reactive species of oxygen, nitrogen, chlorine cause DNA oxidation which is potentiated by exogenous prooxidant factors. The free radicals cause various DNA damages. This review highlights one of them, oxidative modification of guanosine, and also modern methods of the estimation of oxidized guanosine (8-oxodG) content. The numerous data on an induction of 8-oxodG in DNA by exogenous genotoxicants in vitro and in vivo are presented. 8-oxodG is used as a biomarker of DNA oxidation, accompanying some human diseases.
Download PDF:  
Citation:

Zinovjeva, V. N., Ostrovsky, O. V. (2002). DNA oxidation by free radicals and its biomarker oxidizedguanosine (8-oxodG). Voprosy Meditsinskoi Khimii, 48(5), 419-431.
References  
 2002 (vol 48)
 2001 (vol 47)
 2000 (vol 46)
 1999 (vol 45)
 1998 (vol 44)
 1997 (vol 43)
 1996 (vol 42)
 1995 (vol 41)
 1994 (vol 40)
 1993 (vol 39)
 1992 (vol 38)
 1991 (vol 37)
 1990 (vol 36)
 1989 (vol 35)
 1988 (vol 34)
 1987 (vol 33)
 1986 (vol 32)
 1985 (vol 31)