Experimental uveitis is characterized by a pronounced lipid peroxidation (LPO) in damaged tissues of eye, which is complicated by reduced activity of the antioxidant enzymes, SOD and catalase. The intensification of LPO was also found in blood serum and hepatic tissue. However, hepatic lipid peroxidation was accompanied by compensatory increase of catalase activity. The activity of antioxidant defence enzymes decreased in blood, whereas catalase was activated in hepatic tissue. The therapeutic effect was accompanied by a decrease of LPO products and increase of activity of the antioxidant enzymes in all tissues. Treatment of uveitis with gentamycin and, especially, perftoran reduced inflammatory events.
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Karimova M.Kh., Inoyaytova F. Kh. (2002) The effect of perftoran on a course of experimentaluveitis, lipid peroxidation processes and activity of enzymes of antioxidant defense. Voprosy Meditsinskoi Khimii, 48(5), 450-454.
Karimova M.Kh. et al. The effect of perftoran on a course of experimentaluveitis, lipid peroxidation processes and activity of enzymes of antioxidant defense // Voprosy Meditsinskoi Khimii. - 2002. - V. 48. -N 5. - P. 450-454.
Karimova M.Kh. et al., "The effect of perftoran on a course of experimentaluveitis, lipid peroxidation processes and activity of enzymes of antioxidant defense." Voprosy Meditsinskoi Khimii 48.5 (2002): 450-454.
Karimova, M. Kh., Inoyaytova, F. , Kh. (2002). The effect of perftoran on a course of experimentaluveitis, lipid peroxidation processes and activity of enzymes of antioxidant defense. Voprosy Meditsinskoi Khimii, 48(5), 450-454.
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