The activity of NAD(P)-dependent dehydrogenses in bloodlymphocytes by children and adolescents with different duration of insulin-dependentdiabetes mellitus
Savchenko A.A.1 , Krukova E.V.1 , Manchouk V.T.1
1. Institute for Medical Problems of the North, Siberian Division of Russian Academy of Medical Sciences
The levels of blood lymphocyte NAD(P)-dependent dehydrogenases were investigated in children and teenagers with different duration of insulin-dependent diabetes mellitus (IDDM). The level of some NAD(P)-dependent dehydrogenases changed proportionally in dependence of IDDM duration and insulin therapy did not restore their activities to the normal level. It is suggested that these changes may reflect decrease of energy metabolism and plastic processes in blood lymphocytes from diabetic children and teenagers reflecting. These changes correspond to altered functional reactivity of immunocompetent cells and represent metabolic basis of immunopathogenic complications of IDDM.
Download PDF:
Citation:
Savchenko A.A., Krukova E.V., Manchouk V.T. (2002) The activity of NAD(P)-dependent dehydrogenses in bloodlymphocytes by children and adolescents with different duration of insulin-dependentdiabetes mellitus. Voprosy Meditsinskoi Khimii, 48(5), 519-525.
Savchenko A.A. et al. The activity of NAD(P)-dependent dehydrogenses in bloodlymphocytes by children and adolescents with different duration of insulin-dependentdiabetes mellitus // Voprosy Meditsinskoi Khimii. - 2002. - V. 48. -N 5. - P. 519-525.
Savchenko A.A. et al., "The activity of NAD(P)-dependent dehydrogenses in bloodlymphocytes by children and adolescents with different duration of insulin-dependentdiabetes mellitus." Voprosy Meditsinskoi Khimii 48.5 (2002): 519-525.
Savchenko, A. A., Krukova, E. V., Manchouk, V. T. (2002). The activity of NAD(P)-dependent dehydrogenses in bloodlymphocytes by children and adolescents with different duration of insulin-dependentdiabetes mellitus. Voprosy Meditsinskoi Khimii, 48(5), 519-525.
