Polymer dressings with encapsulated thrombin or synthetic peptides which can mimic thrombin action are employed for wound healing. Paper describes the method for preparation of these hydrogel composites of PVCL-CaAlg [poly(N-vinyl caprolactam-calcium alginate). The effect of encapsulated thrombin/peptides on tissue repair process have beet investigatat in vivo experiments using a mouse model of wound healing. The developed dressings accelerated wound healing: thascan be used as a basis for creation of novel formulations with controlled drug release for wound therapy.
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Markvicheva E.A., Kuptsova S.V., Rumsh L.D., Dugina T.N., Lange M.A., Chistov I.V., Strukova S.M., Zubov V.P. (2002) Polymer dressings with encapsulated thrombin orpeptides : preparation and use for wound healing . Voprosy Meditsinskoi Khimii, 48(6), 570-576.
Markvicheva E.A. et al. Polymer dressings with encapsulated thrombin orpeptides : preparation and use for wound healing // Voprosy Meditsinskoi Khimii. - 2002. - V. 48. -N 6. - P. 570-576.
Markvicheva E.A. et al., "Polymer dressings with encapsulated thrombin orpeptides : preparation and use for wound healing ." Voprosy Meditsinskoi Khimii 48.6 (2002): 570-576.
Markvicheva, E. A., Kuptsova, S. V., Rumsh, L. D., Dugina, T. N., Lange, M. A., Chistov, I. V., Strukova, S. M., Zubov, V. P. (2002). Polymer dressings with encapsulated thrombin orpeptides : preparation and use for wound healing . Voprosy Meditsinskoi Khimii, 48(6), 570-576.
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