VOPROSY MEDITSINSKOI KHIMII (ISSN 0042-8809)

Comparative analysis differentiating and apoptogenic effects of cytidine, thymidine and guanosine on human erythroleukaemic K562 cells

   
Volkova T.O.1, Malysheva I. E.1, Nemova N.N.1

1. Petrozavodsk State University
PubMed Id: 12698558
Year: 2002  Volume: 48  Issue: 6  Pages: 586-593
The antiproliferative, differentiating and apoptogenic effects of purinic (cytidine and thymidine) and pyrimidinic (guanosine) nucleosides on K562 cells were investigated. Induction of erythroid differentiation (haemoglobin synthesis) in cancer cells was observed after 2 and 4 days incubation with 2 mM thymidine and 1 mM guanosine. Increase of haemoglobin synthesis in K 562 cells incubated with 2 mM cytidine was detected at 4 day. Analysis of the DNA-degrading effect (induction of apoptosis) of the reagents used on K 562 cells by fluorescent dyes and modulation activity of caspase 9 and also caspases 3,7,10 is induced with thymidine and guanosine but not with cytidine.
Download PDF:  
Citation:

Volkova, T. O., Malysheva, I. , E., Nemova, N. N. (2002). Comparative analysis differentiating and apoptogenic effects of cytidine, thymidine and guanosine on human erythroleukaemic K562 cells. Voprosy Meditsinskoi Khimii, 48(6), 586-593.
References  
 2002 (vol 48)
 2001 (vol 47)
 2000 (vol 46)
 1999 (vol 45)
 1998 (vol 44)
 1997 (vol 43)
 1996 (vol 42)
 1995 (vol 41)
 1994 (vol 40)
 1993 (vol 39)
 1992 (vol 38)
 1991 (vol 37)
 1990 (vol 36)
 1989 (vol 35)
 1988 (vol 34)
 1987 (vol 33)
 1986 (vol 32)
 1985 (vol 31)