The protein composition of the nuclear matrix of normal and tumor cells is discussed. A characteristic feature of the latter is the predominance of high molecular weight polypeptides containing mainly glyco- and phosphoproteins. Only few of them are identified. Nuclear matrix preparations from tumors differ by the presence of fibronectin and phosphotyrosine-containing proteins with a molecular mass of nearly 180 and 170 kDa as well as of high turnover of high molecular weight protein group and inhibition of their biosynthesis by chloramphenicol.
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Keywords: protein phosphorylation, nuclear matrix, normal and tumor cells
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Zbarsky I.B. (1997) Proteins of the nuclear matrix and their phosphorylation in normal and tumor cells. Voprosy Meditsinskoi Khimii, 43(5), 301-307.
et al. Proteins of the nuclear matrix and their phosphorylation in normal and tumor cells // Voprosy Meditsinskoi Khimii. - 1997. - V. 43. -N 5. - P. 301-307.
et al., "Proteins of the nuclear matrix and their phosphorylation in normal and tumor cells." Voprosy Meditsinskoi Khimii 43.5 (1997): 301-307.
Zbarsky, I. B. (1997). Proteins of the nuclear matrix and their phosphorylation in normal and tumor cells. Voprosy Meditsinskoi Khimii, 43(5), 301-307.
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