Combined chemotherapy/gene therapy of tumors based on activation of antitumour preparations with genetic constructions containing cytochromes P450
Sokolov N.N., Yatzenko A.N., Pokrovskaya M.V. Section: Review PubMed Id: 10761211
Year: 1999 Volume: 45 Issue : 6 Pages: 462-471 This article generally reviews new original two-stage approach to an effective treatment of solid cancers by killing tumour cells by the activation of a prodrug after the gene encoding for an activating enzyme has been targeted to the malignant cell. The experimental data concerning gene therapy for malignant tumours by using oxazaphosphorines and cytochrome P450 in a novel combined chemotherapy/cancer gene therapy strategy discussed.Download PDF: Keywords: cytochromes P450, cyclophosphamide, lfosfamide, suicide genes, chemotherapy, gene therapy
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Sokolov N.N., Yatzenko A.N., Pokrovskaya M.V. (1999) Combined chemotherapy/gene therapy of tumors based on activation of antitumour preparations with genetic constructions containing cytochromes P450. Voprosy Meditsinskoi Khimii, 45 (6), 462-471.
Sokolov N.N. et al. Combined chemotherapy/gene therapy of tumors based on activation of antitumour preparations with genetic constructions containing cytochromes P450 // Voprosy Meditsinskoi Khimii. - 1999. - V. 45. -N 6. - P. 462-471.
Sokolov N.N. et al., "Combined chemotherapy/gene therapy of tumors based on activation of antitumour preparations with genetic constructions containing cytochromes P450." Voprosy Meditsinskoi Khimii 45.6 (1999): 462-471.
Sokolov, N. N., Yatzenko, A. N., Pokrovskaya, M. V. (1999). Combined chemotherapy/gene therapy of tumors based on activation of antitumour preparations with genetic constructions containing cytochromes P450. Voprosy Meditsinskoi Khimii , 45(6), 462-471.
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