VOPROSY MEDITSINSKOI KHIMII (ISSN 0042-8809)

Combined chemotherapy/gene therapy of tumors based on activation of antitumour preparations with genetic constructions containing cytochromes P450

   
Sokolov N.N., Yatzenko A.N., Pokrovskaya M.V.
Section: Review
PubMed Id: 10761211
Year: 1999  Volume: 45  Issue: 6  Pages: 462-471
This article generally reviews new original two-stage approach to an effective treatment of solid cancers by killing tumour cells by the activation of a prodrug after the gene encoding for an activating enzyme has been targeted to the malignant cell. The experimental data concerning gene therapy for malignant tumours by using oxazaphosphorines and cytochrome P450 in a novel combined chemotherapy/cancer gene therapy strategy discussed.
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Sokolov N.N., Yatzenko A.N., Pokrovskaya M.V. (1999) Voprosy meditsinskoi khimii, 45(6), 462-471.
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