VOPROSY MEDITSINSKOI KHIMII (ISSN 0042-8809)

Effect of histochrome, an antioxidant drug, on contractility and metabolism of isolated rat heart in "calcium paradox", ischemia and reperfusion

   
Winokurov A.A.1, Alabovsky V.V.1, Shulzhenko V.S.1, Ivanova M.V.1, Lebedev A.V.1

1. Voronezh State Medical Academy, Studencheskaya Street 10, Voronezh 394622 (Russia); Institute of Experimental Cardiology, Cardiology Research Center
PubMed Id: 11766258
Year: 2001  Volume: 47  Issue: 5  Pages: 483-490
A comparative study of protective effect of a new antioxidant histochrome on isolated rat heart at calcium paradox and ischemia-reperfusion was carried out. Perfusion with Ca-containing solution after 10-min perfusion with Ca-free medium caused depletion of high energy phosphates, loss of myoglobin, uncoupling of mitochondria, increase of left ventricular diastolic pressure. Pretreatment with histochrome led to decrease of cardiomyocyte damage evaluated by myoglobin efflux in perfused solution, attenuation of decrease ATP and phosphocreatine, and coupling of mitochondria. This resulted in a decrease of left ventricular diastolic pressure at calcium paradox. Less effect of histochrome treatment was noted in the case of ischemia-reperfusion model. It was concluded that histochrome effectively prevents heart from abnormalities caused by calcium imbalance in heart.
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Winokurov, A. A., Alabovsky, V. V., Shulzhenko, V. S., Ivanova, M. V., Lebedev, A. V. (2001). Effect of histochrome, an antioxidant drug, on contractility and metabolism of isolated rat heart in "calcium paradox", ischemia and reperfusion. Voprosy meditsinskoi khimii, 47(5), 483-490.
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