VOPROSY MEDITSINSKOI KHIMII (ISSN 0042-8809)

The role of reactive oxygen species as signal molecules in tissue metabolism under conditions of oxidative stress

   
Dubinina E.E.1

1. Psychoneurological Bekhterev Institute Russia
PubMed Id: 11925746
Year: 2001  Volume: 47  Issue: 6  Pages: 561-581
This review deals with literature data on the functioning of the reactive oxygen species (ROS) as second messengers. ROS induce various biological processes such as stimulation of protein phosphorylation, Ca(2+)-signaling, phospholipid hydrolysis and transcription factor activation. Physiological significance of the role of biological oxidants in the regulation of signal transduction and the mechanisms of the adaptation of organism to extremital conditions are discussed. Oxidative stress is a common step for the development of many diseases characterized by the intensive ROS generation.
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Dubinina, E. E. (2001). The role of reactive oxygen species as signal molecules in tissue metabolism under conditions of oxidative stress. Voprosy meditsinskoi khimii, 47(6), 561-581.
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