Three-hours intoxication induced by sublethal doses of autolysate or of fraction II of Pasteurella pestis EV in albino rats, guinea pigs and Meriones meridianus nogaiorum Heptn. resulted in a decrease of glycogen content in liver and calf muscles. In albino rats which are highly sensitive to plague toxin, this decrease was more significant compared to more resistant guinea pigs. Under the action of plague toxin on myocardium of Meriones and guinea pigs, glycogen content decreased while in albino rats increased. Plaque intoxication resulted in a statistically significant decrease of ascorbic acid concentration in adrenal gland and in liver in all rodent species studied.