VOPROSY MEDITSINSKOI KHIMII (ISSN 0042-8809)

Effect of experimental hyper- and hypothyrosis on the level of various forms of vitamin A in various tissues of albino rats

   
Natanson A.O., Grigor'eva L.V.
PubMed Id: 5317627
Year: 1971  Volume: 17  Issue: 4  Pages: 411-414
A method allowing simultaneous assay of the tissue content of three forms of vitamin A (alcohol, ester, aldehyde) was applied for investigation of these forms in liver, kidneys, adrenals and blood plasma in rats with experimental hyper- and hypothyreosis. It is established that compared to control rats, hyperthyroid animals show increased content of vitamin A-alcohol in adrenals with simultaneous decrease in liver of vitamin A-alcohol and especially of its ester. It is supposed that these changes are directly induced by the action of thyroxine on vitamin A metabolism in tissues. During hyperthyreosis, content of vitamin A (alcohol and ester) in liver sharply falls and there is a tendency towards its decrease on blood plasma and adrenals. Approximately the same ratio of alcohol and ester of vitamin A in kidneys indicated its intensive metabolism in this organ. As judged from the absence of changes in content of vitamin A-aldehyde in organs, activation as well as suppression of the function of thyroid gland apparently is not followed by an increase in oxidative transformation of vitamin A in tissues.
Download PDF:
Reference:

Natanson A.O., Grigor'eva L.V. (1971) Voprosy meditsinskoi khimii, 17(4), 411-414.
References
 1984 (vol 30)
 1983 (vol 29)
 1982 (vol 28)
 1981 (vol 27)
 1980 (vol 26)
 1979 (vol 25)
 1978 (vol 24)
 1977 (vol 23)
 1976 (vol 22)
 1975 (vol 21)
 1974 (vol 20)
 1973 (vol 19)
 1972 (vol 18)
 1971 (vol 17)
 1970 (vol 16)
 1969 (vol 15)
 1968 (vol 14)
 1967 (vol 13)
 1966 (vol 12)
 1965 (vol 11)
        

© Institute of Biomedical Chemistry, Moscow, Russia