VOPROSY MEDITSINSKOI KHIMII (ISSN 0042-8809)

Effect of histamine on the hexokinase activity and RNA synthesis in the seminal vesicles and prostate of orchiectomized rats

   
Pankova I.G., Manankova N.M.
PubMed Id: 235173
Year: 1975  Volume: 21  Issue: 1  Pages: 49-53
Due to orchidectomy, carried out two weeks before the experiment, in androgene-dependent rat tissues a hexokinase activity was found to be decreased several times. Within 24 hrs after administration of histamine into orchidectomized rats the hexokinase activity was increased by 96% in seminal follicles and by 160% in prostate. Incorporation of 3H-uridine into RNA of seminal follicles and prostate of castrated rat males was increased by 60% and 210%, respectively, within 3 hrs after the administration of histamine. The stimulating effects of histamine on RNA synthesis and the hexokinase activity were completely inhibited by actinomycin D. The data obtained suggest that histamine was one of mediators in the effect of testosterone on the tissues-targets.
Download PDF:
Reference:

Pankova I.G., Manankova N.M. (1975) Voprosy meditsinskoi khimii, 21(1), 49-53.
References
 1984 (vol 30)
 1983 (vol 29)
 1982 (vol 28)
 1981 (vol 27)
 1980 (vol 26)
 1979 (vol 25)
 1978 (vol 24)
 1977 (vol 23)
 1976 (vol 22)
 1975 (vol 21)
 1974 (vol 20)
 1973 (vol 19)
 1972 (vol 18)
 1971 (vol 17)
 1970 (vol 16)
 1969 (vol 15)
 1968 (vol 14)
 1967 (vol 13)
 1966 (vol 12)
 1965 (vol 11)
        

© Institute of Biomedical Chemistry, Moscow, Russia