Formation of a secondary adrenaline-heparin-fibrinogen complex and its properties

Kudriashov B.A., Liapina L.A., Zhitnikova E.S., Obraztsov V.V.
PubMed Id: 1119113
Year: 1975  Volume: 21  Issue: 1  Pages: 65-69
An effect of increase in fibrinolytic activity of adrenaline-heparin (ADH) complex was studied under its incubation in a mixture with pure fibrinogen on unstablized plates of fibrin in presence of xi-aminocapronic acid, By means of spectrophotometry in UV-light an increase in lytic activity of the incubated mixture of adrenaline-heparin complex with fibrinogen was shown to be due to formation of a secondary complex, which included adrenaline, heparin and fibrinogen. After intravenous administration of a mixture of ADH complex with fibrinogen, containing products of interaction of adrenaline, heparin and fibrinogen, not only an increase in non-enzymic fibrinolytic activity of plasma occurred, but also an increase in duration of an effect of adrenaline--heparin--fibrinogen complex was observed in vivo as compared with the equivalent dose of the ADH complex
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Kudriashov, B. A., Liapina, L. A., Zhitnikova, E. S., Obraztsov, V. V. (1975). Formation of a secondary adrenaline-heparin-fibrinogen complex and its properties. Voprosy Meditsinskoi Khimii, 21(1), 65-69.
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