VOPROSY MEDITSINSKOI KHIMII (ISSN 0042-8809)

Activity of the kallikrein-kinin system in experimental myocardial infarct in dogs and the effect of catecholamines

   
Stukalova T.I., Lazareva S.A., Ternovaia L.A.
PubMed Id: 1119117
Year: 1975  Volume: 21  Issue: 1  Pages: 88-91
In experimental myocardial infarction in dogs even within first minutes after occlusion of coronary artery content of bradikinine was distinctly decreassed in blood plasma, content of kallikrein was increased and the activity of kininase was decreased in blood. These phenomena reflected the activation of kallikrein-kinin system. An increase in content of glutamate-oxaloacetate transaminase was observed only within 6 hrs after ligation of the coronary artery. Content of adrenaline and noradrenaline was increased in the zone of myocardial infarction within 2 days after the onset of the disease; content of the catecholamines was significantly increased (3-17-fold) in adrenal glands. In acute period of myocardial infarction intravenous administration of adrenaline into animals caused a promt, distinct kininogenolytic effect and increased the content of kallikrein in blood. These findings demonstrate a significant effect of adrenaline on kallikrein-kinin system.
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Stukalova, T. I., Lazareva, S. A., Ternovaia, L. A. (1975). Activity of the kallikrein-kinin system in experimental myocardial infarct in dogs and the effect of catecholamines. Voprosy Meditsinskoi Khimii, 21(1), 88-91.
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