VOPROSY MEDITSINSKOI KHIMII (ISSN 0042-8809)

Effect of an inhibitor of a trypsin-like enzyme on the degradation of liver proteins under normal conditions and in thermic burns

   
Zayets T.L., Kotkina T.I.
PubMed Id: 1216758
Year: 1975  Volume: 21  Issue: 4  Pages: 380-382
Degradation of proteins in liver tissue slices, estimated by liberation of 14C-glycine, was increased in the animals which were subjected to burns. The cathepsin D activity was found to be simultaneously increased in extracts of the liver tissue. In burnt rats, administered with an inhibitor of trypsin-like enzymes (contrical) during 8 days after the burning, the rates of protein degradation and the values of cathepsin D activity approached those characteristics for the normal animals. Addition of the inhibitor into incubation samples did not effect degradation of liver tissue proteins and the enzymatic activity.
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Zayets, T. L., Kotkina, T. I. (1975). Effect of an inhibitor of a trypsin-like enzyme on the degradation of liver proteins under normal conditions and in thermic burns. Voprosy Meditsinskoi Khimii, 21(4), 380-382.
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