VOPROSY MEDITSINSKOI KHIMII (ISSN 0042-8809)

Effect of Polyakov's "prints" on the catalytic properties of an enzyme substrate system

   
Grebenschikova O.G., Mardashev Y.S., Mardashen S.R., Patrikeev V.V.
PubMed Id: 175565
Year: 1975  Volume: 21  Issue: 4  Pages: 396-400
Silicagels, formed in presence of an enzyme (histidine decarboxylase from Micrococcus sp. n.), substrate (L-histidine-HCl-H2O) and inhibitor (imidazole) (so-called Polyakov's "print") exhibited specific catalytic properties in the reaction of L-histidine decarboxylation. The "prints" of the enzyme, inhibitor and substrate increased the activity of the enzyme-substrate system studied. The increased activity was probably due to the specific adsorption of imidazole ring of the substrate molecule by the "print".
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Grebenschikova O.G., Mardashev Y.S., Mardashen S.R., Patrikeev V.V. (1975) Voprosy meditsinskoi khimii, 21(4), 396-400.
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