VOPROSY MEDITSINSKOI KHIMII (ISSN 0042-8809)

Stimulation by cyclic adenosine-3'5'-monophosphate by Na+, K+-activated ATPase from rabbit kidney

   
Kuz'min O.B., Smirnov P.A.
PubMed Id: 175566
Year: 1975  Volume: 21  Issue: 4  Pages: 406-409
Cyclic 3',5-AMP in vitro increased the activity of Na+, K+-ATPase, isolated from cortex and medulla of rabbit kidney. Maximal stimulating effect was observed in kidney cortex at 10(-6) M concentration and in medulla at 10(-4) M concentration of 3',5'-AMP. Under these conditions the enzymatic activity was increased by 24.6 +/- 4.1% and 27.9 +/- 7.7%, respectively. These data suggest that Na+, K+-ATPase, activated by cyclic 3',5'-AMP, is directly involved in the mechanism of Na+ transport in cells of osmoregulating organs.
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Kuz'min O.B., Smirnov P.A. (1975) Voprosy meditsinskoi khimii, 21(4), 406-409.
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