VOPROSY MEDITSINSKOI KHIMII (ISSN 0042-8809)

Intensity of incorporation of 2-C14-acetate into the cerebrosides and gangliosides of the brain and spinal cord of rabbits in experimental allergic encephalomyelitis

   
Taranova N.P., Katsnel'son I.P.
PubMed Id: 1025874
Year: 1976  Volume: 22  Issue: 1  Pages: 108-112
In rabbits the acute form of experimental allergic encephalomyelitis was caused by inoculation of emulsion of homologous myelin from spinal cord with Freund's adjuvant. In terminal paralytic period of the disease the animals were subcutaneously administered with 2-14C-acetate and a dose 50 micronCi per 100 g of body weight 2 hrs before death. From lumbar and stem sections of the central nervous system purified fractions of cerebrosides and gangliosides were isolated and their specific radioactivity was determined. The intensity of the cerebrosides synthesis was found to be distinctly decreased not only in the more impaired lumbar region but also in the stem section of the central nervous system, where the centers of demyelinization were not observed. The intensity of the gangliosides synthesis was also markedly decreased, in spite of that their content was not altered in the central nervous system under experimental allergic encephalomyelitis.
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Taranova, N. P., Katsnel'son, I. P. (1976). Intensity of incorporation of 2-C14-acetate into the cerebrosides and gangliosides of the brain and spinal cord of rabbits in experimental allergic encephalomyelitis. Voprosy Meditsinskoi Khimii, 22(1), 108-112.
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