VOPROSY MEDITSINSKOI KHIMII (ISSN 0042-8809)

Effect of carboxycathepsin on biological activity of bradykinin

   
Egorova T.P., Eliseeva I.E.
PubMed Id: 193287
Year: 1976  Volume: 22  Issue: 1  Pages: 119-122
An effect of carboxycathepsin (peptidyl-dipeptidase EC 3.4.15.1) from bovine kidney on bradikinine was studied. The bradikinine activity was determined by monitoring the rat uterine horn retraction. Carboxycathepsin caused rapid inactivation of bradikinine (440-500 mcg of bradikinine/mg/min). The rate of bradikinine inactivation depended on the incubation time, content of the enzyme and substrate in the samples. In presence of EDTA carboxycathepsin did not inactivate bradikinine.
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Egorova, T. P., Eliseeva, I. E. (1976). Effect of carboxycathepsin on biological activity of bradykinin. Voprosy Meditsinskoi Khimii, 22(1), 119-122.
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